Mechanism of TCDD-induced suppression of antibody production: effect on T cell-derived cytokine production in the primary immune reaction of mice.

@article{Ito2002MechanismOT,
  title={Mechanism of TCDD-induced suppression of antibody production: effect on T cell-derived cytokine production in the primary immune reaction of mice.},
  author={Tomohiro Ito and Kaoru Inouye and Hidekazu Fujimaki and Chiharu Tohyama and Keiko Nohara},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2002},
  volume={70 1},
  pages={46-54}
}
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is known to suppress antigen-specific antibody production in humoral immune reactions, but the precise mechanism remains unclear. Since T cell activation and subsequent production of type 2 helper T (Th2) cell-derived cytokines are required for antigen-specific antibody production in humoral immunity, we examined the effects of TCDD on splenic T cell numbers, T cell growth factor IL-2 production, and Th2 cell-derived cytokine production. C57BL/6N mice… CONTINUE READING
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Low-dose exposure to dioxin, its toxicities and health risk assessment

  • C. Tohyama
  • Environ. Sci
  • 2002
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