Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury.

@article{Nutku2005MechanismOS,
  title={Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury.},
  author={Esra Nutku and Sherry A. Hudson and Bruce S Bochner},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={336 3},
  pages={918-24}
}
Sialic acid binding immunoglobulin like lectin (Siglec)-8 crosslinking with specific antibodies causes human eosinophil apoptosis. Mechanisms by which Siglec-8 crosslinking induces apoptosis are not known. Peripheral blood eosinophils were examined for caspase, mitochondria and reactive oxygen species (ROS) involvement after incubating the cells with anti… CONTINUE READING