Mechanism of Roux-en-Y Gastric Bypass Treatment for Type 2 Diabetes in Rats

@inproceedings{Yu2013MechanismOR,
  title={Mechanism of Roux-en-Y Gastric Bypass Treatment for Type 2 Diabetes in Rats},
  author={Hongwei Yu and Xiyan Zheng and Zongming Zhang},
  booktitle={Journal of Gastrointestinal Surgery},
  year={2013}
}
Roux-en-Y gastric bypass (RYGB) is a novel therapy for diabetes. We aimed to explore the therapeutic mechanism of RYGB. After RYGB, animal models were established, and gene expression profile of islets was assessed. Additionally, gastrointestinal hormones were measured using enzyme-linked immunosorbent assays. Ca2+ was studied using confocal microscopy and patch-clamp technique. The morphology of islets and beta cells was observed using optical microscopy and electron microscopy. RYGB was an… CONTINUE READING