Mechanism of Residence of Cytochrome B(5), a Tail-Anchored Protein, in the Endoplasmic Reticulum

@article{Pedrazzini2000MechanismOR,
  title={Mechanism of Residence of Cytochrome B(5), a Tail-Anchored Protein, in the Endoplasmic Reticulum},
  author={Emanuela Pedrazzini and Antonello Villa and Renato Longhi and Alessandra Bulbarelli and Nica Borgese},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={148},
  pages={899 - 914}
}
Endoplasmic reticulum (ER) proteins maintain their residency by static retention, dynamic retrieval, or a combination of the two. Tail-anchored proteins that contain a cytosolic domain associated with the lipid bilayer via a hydrophobic stretch close to the COOH terminus are sorted within the secretory pathway by largely unknown mechanisms. Here, we have investigated the mode of insertion in the bilayer and the intracellular trafficking of cytochrome b(5) (b[5]), taken as a model for ER… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 64 references

A role

  • N. Borgese, J. R. Harris, +5 authors M. Bassetti
  • 1996
Highly Influential
3 Excerpts

The targeting information

  • M. 1343–1355. De Silvestris, A. D’Arrigo, N. Borgese
  • 1995
Highly Influential
4 Excerpts

Evidence for a COP-I-indepen

  • Lord, T. Nilsson, R. Pepperkok
  • 1999

Evidence for a COPI - independent transport route from the Golgi complex to the endoplasmic reticulum

  • J. Mitoma, A. Ito
  • Nat . Cell Biol .
  • 1998

Similar Papers

Loading similar papers…