Mechanism of Rectification in Inward-rectifier K+ Channels

  title={Mechanism of Rectification in Inward-rectifier K+ Channels},
  author={Donglin Guo and Yajamana Ramu and Angela M. Klem and Zhe Lu},
  journal={The Journal of General Physiology},
  pages={261 - 276}
Inward rectifiers are a class of K+ channels that can conduct much larger inward currents at membrane voltages negative to the K+ equilibrium potential than outward currents at voltages positive to it, even when K+ concentrations on both sides of the membrane are made equal. This conduction property, called inward rectification, enables inward rectifiers to perform many important physiological tasks. Rectification is not an inherent property of the channel protein itself, but reflects strong… CONTINUE READING
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Structural basis of inward rectification : Cytoplasmic pore of the G protein - gated inward rectifier GIRK 1 at 1 . 8 Å resolution

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  • 2002

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