Mechanism of RNA synthesis initiation by the vesicular stomatitis virus polymerase.

@article{Morin2012MechanismOR,
  title={Mechanism of RNA synthesis initiation by the vesicular stomatitis virus polymerase.},
  author={B. Morin and Amal A. Rahmeh and Sean P J Whelan},
  journal={The EMBO journal},
  year={2012},
  volume={31 5},
  pages={1320-9}
}
The minimal RNA synthesis machinery of non-segmented negative-strand RNA viruses comprises a genomic RNA encased within a nucleocapsid protein (N-RNA), and associated with the RNA-dependent RNA polymerase (RdRP). The RdRP is contained within a viral large (L) protein, which associates with N-RNA through a phosphoprotein (P). Here, we define that vesicular stomatitis virus L initiates synthesis via a de-novo mechanism that does not require N or P, but depends on a high concentration of the first… CONTINUE READING

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