Mechanism of Puberty

@article{Brook1999MechanismOP,
  title={Mechanism of Puberty},
  author={C. G. D. Brook},
  journal={Hormone Research in Paediatrics},
  year={1999},
  volume={51},
  pages={52 - 54}
}
  • C. Brook
  • Published 1 November 1999
  • Biology, Medicine
  • Hormone Research in Paediatrics
The hypothalamo-pituitary-gonadal axis in children is fully functional in fetal life and immediately after birth. The reason why it declines with advancing years of childhood is not clear but gonadotropin pulsatility is at a nadir at 6 years of age. From that time pulsatile gonadotropin starts to reappear but, again, the reason why this happens is completely unknown. All of the events of puberty can be ascribed to pulsatile gonadotropin-releasing hormone stimulation causing pulsatile… 
GH as a co-gonadotropin: the relevance of correlative changes in GH secretion and reproductive state.
TLDR
Correlative changes in GH secretion and reproductive state (puberty, pregnancy, lactation, menopause and ovarian cycles) are thus the primary focus of this review.
Development and maturation of the male reproductive system.
TLDR
This review briefly describes some of the key events in the postnatal development of the male reproductive system in humans, non-human primates, rats, and dogs, and provides an initial overview of these processes.
Congenital adrenal hyperplasia, cyp21a2 deficiency : clinical and physiological aspects of pregnancy, screening and growth
TLDR
Results indicate that gestational age at birth, but not prenatal growth, is affected by androgen exposure, and that screening for CAH does not only increase the number of detected boys with SW CAH as previously thought, but also of girls.
Pituitary Remodeling Throughout Life: Are Resident Stem Cells Involved?
TLDR
Pituitary plasticity conditions are described and what is known on the involvement and phenotype of pituitary stem cells during these pituitsary remodeling events are summarized.
Determinants of pubertal development in an urban South African cohort
TLDR
The main aims of this study were to investigate the timing of, and the early life factors associated with pubertal development and age at menarche in Black and White urban South African adolescents, and logistic regression models showed that a greater weight and height velocity in late childhood significantly increased the odds of achieving early breasU genitalia development.
Central precocious puberty may be a manifestation of endocrine dysfunction in pediatric patients with mitochondrial disease
TLDR
Serum estradiol levels were significantly higher in younger patients than in older patients, and central PP may be a manifestation of endocrine dysfunction in young girls with MDs.
The development of psychotic disorders in adolescence: A potential role for hormones
Pubertal development in ICSI children.
TLDR
It is found that pubertal development, characterized by menarche, genital development in males and pubic hair development in females, was comparable in the ICSI and SC groups.
Kisspeptin, a Novel Hypothalamic Regulator of the Somatotropic and Gonadotropic Axes in Ruminants
TLDR
This chapter discusses the interaction of kisSPEPTIN and the SOMATOTROPIC AXIS in ruminants, and the effects of status and stage on this interaction and the results are summarized in chapter V.
...
...

References

SHOWING 1-10 OF 10 REFERENCES
Growth hormone increases rate of pubertal maturation.
TLDR
It is suggested that GH accelerates the pubertal process and skeletal maturity at the onset of puberty was not advanced excluding this as a contributory factor.
Changes in gonadotrophin secretion during childhood and puberty.
TLDR
It is shown that LH levels do not reach a nadir until 8 years of age, and a sex difference in the pattern of LH secretion seen in early puberty is detected, and this mirrors clinical findings.
Ovarian ultrasound assessment in normal children, idiopathic precocious puberty, and during low dose pulsatile gonadotrophin releasing hormone treatment of hypogonadotrophic hypogonadism.
TLDR
Ultrasound assessment of ovarian volume, follicular size, and uterine growth was undertaken in 40 normal premenarcheal girls and eight girls with idiopathic precocious puberty had large megalocystic ovaries which regressed on treatment with gonadotrophin releasing hormone analogue.
Gonadotropin secretion in prepubertal normal and agonadal children evaluated by ultrasensitive time-resolved immunofluorometric assays.
TLDR
It is suggested that during this period of life the gonads contribute to the negative feedback regulation of gonadotropin levels during the prepubertal period, as measured in children with primary gonadal failure.
A diphasic pattern of gonadotropin secretion in patients with the syndrome of gonadal dysgenesis.
TLDR
The similarity of pattern of Gonadotropin secretion observed between patients with gonadal dysgenesis and normal children suggests that gonadal function does not play a decisive role in the pattern of gonadotropic secretion from infancy through adolescence, but exercises striking effects on the quantity of gonADotropin secreted.
Comparison of pulsatile luteinizing hormone secretion between prepubertal children and young adults: evidence for a mass/amplitude-dependent difference without gender or day/night contrasts.
TLDR
It is concluded that the maturational change in LH secretion occurs via a highly specific mass/amplitude-dependent mechanism without significant gender or day/night differences.
Interrelationships of skeletal maturation, sexual development and somatic growth in man.
TLDR
The data suggest that the ossification of the skeleton in prepubertal children is independent of those maturational processes which lead to the development of the secondary sex characters and not dependent upon a relationship between skeletal age and the attainment of peak height velocity.
Sexual precocity: sex incidence and aetiology.
TLDR
All boys with precocious puberty need detailed investigation; in girls investigation should be based on clinical findings, particularly the consonance of puberty.