Mechanism of Prophylaxis by Silver Compounds against Infection of Burns

  title={Mechanism of Prophylaxis by Silver Compounds against Infection of Burns},
  author={Colin R Ricketts and Edward Joseph Lister Lowbury and John C. Lawrence and M Hall and M. D. Wilkins},
  journal={British Medical Journal},
  pages={444 - 446}
To clarify tthe mechanism by which local application of silver compounds protects burns against infection, an ion-specific electrode was used to measùre the concentration of silver ions in solutions. By this method it was shown that in burn dressings silver ions were reduced to a very low level by precipitation as silver chloride. The antibacterial effect was found to depend on the availability of silver ions from solution in contact with precipitate. Between 10-5 and 10-6 molar silver nitrate… Expand
Mechanism of Silver Sulfadiazine Action on Burn Wound Infections
The efficacy of silver sulfadiazine is thought to result from its slow and steady reactions with serum and other sodium chloride-containing body fluids, which permits the slow and sustained delivery of silver ions into the wound environs. Expand
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This article collects together a number of presentations that were given at the 2003 European Burns Association Meeting on the use of Acticoat in the management of burns. Expand
Effect of silver on burn wound infection control and healing: review of the literature.
The present review aims at examining all available evidence about effects of silver on wound infection control and on wound healing trying to determine the practical therapeutic balance between antimicrobial activity and cellular toxicity. Expand
Antimicrobial activity and action of silver.
This chapter discusses antimicrobial activity and action of silver, one of the native metals and second only to gold in its stability amongst the metals of antiquity, and its salts and complexes with proteins and other macromolecules. Expand
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Silver remains a reasonable addition to the armamentarium against infection and has relatively few side effects, however, one should weigh the benefits of silver-containing products against the known side effects and the other options available for the intended purpose when selecting the most appropriate therapy. Expand
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Hard to heal wounds are painful and the patient has to stand with them for a long time, also these wounds are an economical burden for health care systems. One important factor that may interrupt theExpand
A new technology of microdispersed silver in polyurethane induces antimicrobial activity in central venous catheters
Silver ions have an affinity to sulfhydryl groups in enzyme systems of the cell wall, through which they interfere with the transmembranous energy transfer and electron transport of bacterial microorganisms, and block the respiratory chain of microorganisms reversibly in low concentrations and irreversibly in higher concentrations. Expand
Topical chemoprophylaxis for burns: trials of creams containing silver sulphadiazine and trimethoprim.
Silver sulphadiazine cream was well tolerated by patients and considered to be a suitable agent for prophylactic use, and in an interim assessment of a controlled therapeutic trial, silver sulphad Diazine cream appeared to have some therapeutic value. Expand
Silver, biofilms and wounds: resistance revisited
There still remains very little evidence that silver resistance is a growing health concern in wound care; more studies are clearly needed to substantiate this concern, which has not been observed clinically to any major degree. Expand


Study on the Effects of Tablet Colour in the Treatment of Anxiety States
The results indicate that colour may play a part in the response to a drug, and symptoms of anxiety were most improved with green, whereas depressive symptoms appeared to respond best to yellow. Expand
British Journal of Pharmacology and Chemotherapy
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THE British Pharmacological Society proposes to establish a new journal with the above title, to be published by the British Medical Association. Pharmacology and chemotherapy are two aspects of theExpand
446-449 Summary: Forty-eight patients with anxiety states were
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