Corpus ID: 5018733

Mechanism of Phospholipid Complex and its SNEDDS Enhancing the Oral Bioavailability of Silybin

@inproceedings{Zhang2013MechanismOP,
  title={Mechanism of Phospholipid Complex and its SNEDDS Enhancing the Oral Bioavailability of Silybin},
  author={Qin Zhang and Limei Han and Jing Qin and Jianxin Wang},
  year={2013}
}
SUMMARY The mechanisms of silybin–phospholipid complex (SIB–PC) and SIB-PC self-nanoemulsion drug delivery system (SIB-PC-SNEDDS) enhancing the oral bioavailability of SIB were studied by using dynamic in vitro digestion model, transport across Caco-2 cells, measurement of cell membrane fluidity and tight junction protein, in situ perfusion and intestinal lymphatic transport experiment. INTRODUCTION Enhanced bioavailability of BCS II to BCS IV drugs by preparing into phospholipid complex (PC… Expand

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References

SHOWING 1-3 OF 3 REFERENCES
and W
  • N. Charman, Advanced drug delivery reviews,
  • 2001
and E
  • Perucca, European journal of drug metabolism and pharmacokinetics,
  • 1990
and P