Mechanism of PLC-mediated Kir3 current inhibition.

  title={Mechanism of PLC-mediated Kir3 current inhibition.},
  author={Inna Keselman and Miguel Fribourg and Dan Felsenfeld and Diomedes E. Logothetis},
  volume={1 2},
A large number of ion channels maintain their activity through direct interactions with phosphatidylinositol bisphosphate (PIP2). For such channels, hydrolysis of PIP2 causes current inhibition. It has become controversial whether the inhibitory effects on channel activity represent direct effects of PIP2 hydrolysis or of downstream PKC action. We studied Phospholipase C (PLC)-dependent inhibition of G protein-activated inwardly rectifying K+ (Kir3) channels. By monitoring simultaneously… CONTINUE READING


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