Mechanism of Oncogenic Signal Activation by the Novel Fusion Kinase FGFR3-BAIAP2L1.

@article{Nakanishi2015MechanismOO,
  title={Mechanism of Oncogenic Signal Activation by the Novel Fusion Kinase FGFR3-BAIAP2L1.},
  author={Yoshito Nakanishi and Nukinori Akiyama and Toshiyuki Tsukaguchi and Toshihiko Fujii and Yasuko Satoh and Nobuya Ishii and Masahiro Aoki},
  journal={Molecular cancer therapeutics},
  year={2015},
  volume={14 3},
  pages={704-12}
}
Recent cancer genome profiling studies have identified many novel genetic alterations, including rearrangements of genes encoding FGFR family members. However, most fusion genes are not functionally characterized, and their potentials in targeted therapy are unclear. We investigated a recently discovered gene fusion between FGFR3 and BAI1-associated protein 2-like 1 (BAIAP2L1). We identified 4 patients with bladder cancer and 2 patients with lung cancer harboring the FGFR3-BAIAP2L1 fusion… CONTINUE READING

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