Mechanism of Neurotensin Stimulation of External Pancreatic Secretion in the Rat

@article{Nagain1993MechanismON,
  title={Mechanism of Neurotensin Stimulation of External Pancreatic Secretion in the Rat},
  author={Claire Nagain and Jacques Chariot and Claude Roz{\'e}},
  journal={Pancreas},
  year={1993},
  volume={8},
  pages={346–353}
}
The gut and brain peptide neurotensin has been claimed to directly or indirectly stimulate external pancreatic secretion. The purpose of this study was to analyze the mechanism of the neurotensin effect on external pancreatic secretion in the rat. The pancreatic dose-response curve to 40-min venous infusions of neurotensin 1–13 (0.1–10 μg/kg-h = 0.06–6 nmol/kg-h) was biphasic; the maximal response occurred at 3.16 μg/kg-h and reached −30% of the maximal response to cholecystokinin (CCK). The ED… 

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