Mechanism of Neuronal versus Endothelial Cell Uptake of Alzheimer's Disease Amyloid β Protein

@article{Kandimalla2009MechanismON,
  title={Mechanism of Neuronal versus Endothelial Cell Uptake of Alzheimer's Disease Amyloid β Protein},
  author={Karunya K. Kandimalla and Olenych G. Scott and Smita Fulzele and Michael W. Davidson and J. F. Poduslo},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={510 - 518}
}
Alzheimer's disease (AD) is characterized by significant neurodegeneration in the cortex and hippocampus; intraneuronal tangles of hyperphosphorylated tau protein; and accumulation of beta-amyloid (Abeta) proteins 40 and 42 in the brain parenchyma as well as in the cerebral vasculature. The current understanding that AD is initiated by the neuronal accumulation of Abeta proteins due to their inefficient clearance at the blood-brain-barrier (BBB), places the neurovascular unit at the epicenter… CONTINUE READING

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