Mechanism of Nerve-Impulse Transmission at a Crayfish Synapse

  title={Mechanism of Nerve-Impulse Transmission at a Crayfish Synapse},
  author={E. J. Furshpan and Douglas D. Potter},
MICROELECTRODES have been inserted into both pre- and post-junctional elements of certain one-way synapses in the abdominal nerve-cord of the crayfish (Astacus fluviatilis). The pre-synaptic fibres are giant axons (lateral and medial) which run through the length of the cord. The post-fibre is, in each case, the largest of the motor axons which leave the ganglion in the third root. Fig. 1 shows an example of nerve-impulse transmission across such a synapse. The pre-junctional axon was… 

A study on the mechanism of impulse transmission across the giant synapse of the squid

An attempt is made to elucidate the mechanism of impulse transmission across this giant synapse of the squid by using various techniques.

On the search for the electrical synapse: a glimpse at the future

Electrophysiological recording of gap-junctional communication supports its importance in network behavior and direct coupling by electrotonic synapses is now accepted to provide a second major pathway contributing to normal and abnormal physiological rhythms.

Conductance and dye permeability of a rectifying electrical synapse

GMS conductance and dye permeability at thoracic and abdominal levels of the crayfish nerve cord are examined to provide a framework for understanding the operation and functional limits of rectifying electrical synapses, and illustrate that dye permeable can be associated even with their relatively low conductance condition.

The mechanism of rectification at the electrotonic motor giant synapse of the crayfish

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A comparative approach to the problems of synaptic excitation and inhibition is adopted, which is especially concerned with those synaptic transmissions where there is antagonism between excitatory and inhibitory actions.

Structure activity relationship of synaptic and junctional neurotransmission

Electrotonic Coupling in the Nervous System

Several lines of anatomical and pharmacological evidence have shown that this structure is the gap junction intercellular channel that permits the direct flow of electrical current between coupled cells, thus obviating the need for a neurochemically mediated step.

Modulation of cholinergic synaptic transmission in an identified locust sensory pathway

Electrophysiological experiments indicate that presynaptic muscarinic cholinergic receptors are involved in the down-regulation of acetylcholine release from the f SR terminals and at least some of these are located on and activate GABAergic interneurons that inhibit the fSR.

The relationship between the mode of operation and the dimensions of the junctional regions at synapses and motor end-organs

  • J. EcclesJ. Jaeger
  • Biology
    Proceedings of the Royal Society of London. Series B - Biological Sciences
  • 1958
An attempt has been made to correlate the dimensions of synapses as revealed by electron-microscopy with their functional operation, and it is shown that with some synapses the time course of this elimination is satisfactorily described by these equations for both geometrical types ofsynapses.

Mixed neurotransmission in the hippocampal mossy fibers

Dye coupling between these types of principal cells and ultrastructural studies showing the co-existence of AMPA receptors and connexin 36 in this synapse corroborate their presence, and a deeper consideration of mixed neurotransmission taking place in thissynapse may expand the search and understanding of communication channels between different regions of the mammalian CNS.


Changes in end‐plate activity produced by pre‐synaptic polarization

By passing polarizing currents through the terminal portion of a motor axon and studying their effects from the other side of the synapse, it was hoped to get further information on the neuromuscular mechanism.