Mechanism of Local and Global Ca2+ Sensing by Calmodulin in Complex with a Ca2+ Channel

  title={Mechanism of Local and Global Ca2+ Sensing by Calmodulin in Complex with a Ca2+ Channel},
  author={Michael R Tadross and Ivy E. Dick and David T. Yue},
Calmodulin (CaM) in complex with Ca(2+) channels constitutes a prototype for Ca(2+) sensors that are intimately colocalized with Ca(2+) sources. The C-lobe of CaM senses local, large Ca(2+) oscillations due to Ca(2+) influx from the host channel, and the N-lobe senses global, albeit diminutive Ca(2+) changes arising from distant sources. Though biologically essential, the mechanism underlying global Ca(2+) sensing has remained unknown. Here, we advance a theory of how global selectivity arises… CONTINUE READING

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