Mechanism of Interaction of Vitamin E and Glutathione in the Protection against Membrane Lipid Peroxidation

@article{Scholz1989MechanismOI,
  title={Mechanism of Interaction of Vitamin E and Glutathione in the Protection against Membrane Lipid Peroxidation},
  author={Richard W. Scholz and Kenneth S. Graham and Eric Gumpricht and C. Channa Reddy},
  journal={Annals of the New York Academy of Sciences},
  year={1989},
  volume={570}
}
Although the function of vitamin E as the major, if not only, chain-breaking, lipidsoluble antioxidant in biological membranes has been established,’ its mode( s) of action has yet to be elucidated. One proposed mechanism of vitamin E function involves a possible glutathione-dependent system that inhibits in vitro lipid peroxidation. Previously, we have described a rat liver microsomal system that inhibited both enzymatic and nonenzymatic lipid peroxidation in the presence of both glutathione… 

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Natural Compounds with Antioxidant Activity-Used in the Design of Functional Foods

  • P. Savescu
  • Biology
    Functional Foods [Working Title]
  • 2021
TLDR
This chapter is intended to describe the main antioxidants used in the design and construction of functional foods and the importance of some coenzymes in preserving the activity of some valuable bio-compounds (with the role of antioxidants) in functional foods will be highlighted.
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References

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The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E.

TLDR
The involvement of GSH in an enzyme-dependent mechanism is suggested, which exerts an antioxidant effect both in controls and in vitamin E deficiency by decreasing the slope of the chemiluminescence increase during lipid peroxidation.