Mechanism of Interaction of Vitamin E and Glutathione in the Protection against Membrane Lipid Peroxidation

  title={Mechanism of Interaction of Vitamin E and Glutathione in the Protection against Membrane Lipid Peroxidation},
  author={Richard W. Scholz and Kenneth S. Graham and Eric Gumpricht and C. Channa Reddy},
  journal={Annals of the New York Academy of Sciences},
Although the function of vitamin E as the major, if not only, chain-breaking, lipidsoluble antioxidant in biological membranes has been established,’ its mode( s) of action has yet to be elucidated. One proposed mechanism of vitamin E function involves a possible glutathione-dependent system that inhibits in vitro lipid peroxidation. Previously, we have described a rat liver microsomal system that inhibited both enzymatic and nonenzymatic lipid peroxidation in the presence of both glutathione… Expand
Effect of Vitamin E on Glutathione-Dependent Enzymes
This manuscript reviews the interaction between the two defense systems, vitamin E and glutathione-dependent enzymes and concludes that reality is somewhat more complicated. Expand
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The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E.
The involvement of GSH in an enzyme-dependent mechanism is suggested, which exerts an antioxidant effect both in controls and in vitamin E deficiency by decreasing the slope of the chemiluminescence increase during lipid peroxidation. Expand
Vitamin E dependent reduced glutathione inhibition of rat liver microsomal lipid peroxidation.
Effects of reduced glutathione (GSH) were investigated on in vitro lipid peroxidation of hepatic microsomes obtained from Long-Evans Hooded rats fed chemically defined, purified diets containingExpand
Glutathione-dependent protection by rat liver microsomal protein against lipid peroxidation.
  • R. Burk
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 1983
Results indicate the existence of a GSH-dependent rat liver microsomal protein which scavenges free radicals and may be an important defense against free radical injury to the microsome membrane. Expand
Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes?
It is concluded that vitamin E, which is largely present as alpha-tocopherol, is the only significant lipid-soluble, chain-breaking type of antioxidant present in human blood. Expand