Mechanism of Interaction of Vitamin E and Glutathione in the Protection against Membrane Lipid Peroxidation

  title={Mechanism of Interaction of Vitamin E and Glutathione in the Protection against Membrane Lipid Peroxidation},
  author={Richard W. Scholz and Kenneth S. Graham and Eric Gumpricht and C. Channa Reddy},
  journal={Annals of the New York Academy of Sciences},
Although the function of vitamin E as the major, if not only, chain-breaking, lipidsoluble antioxidant in biological membranes has been established,’ its mode( s) of action has yet to be elucidated. One proposed mechanism of vitamin E function involves a possible glutathione-dependent system that inhibits in vitro lipid peroxidation. Previously, we have described a rat liver microsomal system that inhibited both enzymatic and nonenzymatic lipid peroxidation in the presence of both glutathione… 

Effect of Vitamin E on Glutathione-Dependent Enzymes

This manuscript reviews the interaction between the two defense systems, vitamin E and glutathione-dependent enzymes and concludes that reality is somewhat more complicated.

NADPH-dependent inhibition of lipid peroxidation in rat liver microsomes.

The efficacy of vitamin E and melatonin as antioxidants against lipid peroxidation in rat retinal homogenates

Although the IC50 value for melatonin is about 7.2 times higher than that of vitamin E, melatonin's pharmacological and physiological role in the treatment and/or prevention of certain retinal diseases in vivo should be further investigated.

Mechanisms of Trazodone‐Induced Cytotoxicity and the Protective Effects of Melatonin and/or Taurine toward Freshly Isolated Rat Hepatocytes

Trazodone caused an increase in reactive oxygen species (ROS) formation, malondialdehyde accumulation, depletion of intracellular reduced glutathione (GSH), rise of oxidized glutathion disulfide (GSSG), and a decrease in mitochondrial membrane potential, which confirms the role of oxidative stress in trazodone‐induced cytotoxicity.

A role for Sel-Plex™, a source of organic selenium in selenised yeast cell wall protein, as a factor that influences meat stability

Selenium is an important mineral required in the antioxidant system in animals, which is involved with oxidative stability in tissues, particularly membranes, and is involved in various aspects of

Inhibitory Effect of Glutathione on Oxidative Liver Injury Induced by Dengue Virus Serotype 2 Infections in Mice

GSH prevents DV2-induced oxidative stress and liver injury in mice by inhibiting proinflammatory cytokine production, and GSH and may be a promising therapeutic agent for prevention of oxidative liver damage during DV infection.

Natural Compounds with Antioxidant Activity-Used in the Design of Functional Foods

  • P. Savescu
  • Biology
    Functional Foods [Working Title]
  • 2021
This chapter is intended to describe the main antioxidants used in the design and construction of functional foods and the importance of some coenzymes in preserving the activity of some valuable bio-compounds (with the role of antioxidants) in functional foods will be highlighted.



The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E.

The involvement of GSH in an enzyme-dependent mechanism is suggested, which exerts an antioxidant effect both in controls and in vitamin E deficiency by decreasing the slope of the chemiluminescence increase during lipid peroxidation.