Mechanism of Initiation Complex Formation

@inproceedings{McHenry2015MechanismOI,
  title={Mechanism of Initiation Complex Formation},
  author={Charles S McHenry},
  year={2015}
}
An initiation complex is an assembly of the DNA polymerase III holoenzyme (Pol III HE) in which the b2 ring-like processivity factor (sliding clamp) is assembled around DNA in a reaction that is driven by ATP hydrolysis within the DnaX complex (clamp loader). After b2 loading, DNA polymerase III (Pol III) is chaperoned onto b2 and positioned onto the primer terminus, ready to synthesize DNA at a high rate with enormous processivity. The mechanism used by the DnaX complex to drive the assembly… CONTINUE READING

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