Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus

  title={Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus},
  author={Andrew I Flyak and Philipp A. Ilinykh and Charles D. Murin and Tania M Garron and Xiaoli Shen and Marnie L. Fusco and Takao Hashiguchi and Zachary A. Bornholdt and James C Slaughter and Gopal Sapparapu and Curtis M Klages and Thomas Ksiazek and Andrew B. Ward and Erica Ollmann Saphire and Alexander Bukreyev and James E. Crowe},
The mechanisms by which neutralizing antibodies inhibit Marburg virus (MARV) are not known. We isolated a panel of neutralizing antibodies from a human MARV survivor that bind to MARV glycoprotein (GP) and compete for binding to a single major antigenic site. Remarkably, several of the antibodies also bind to Ebola virus (EBOV) GP. Single-particle EM… CONTINUE READING