Mechanism of Helcobacter pylori Pathogenesis: Focus on Mucus

  title={Mechanism of Helcobacter pylori Pathogenesis: Focus on Mucus},
  author={B. L. Slomiany and Amalia Slomiany},
  journal={Journal of Clinical Gastroenterology},
Although the clinical data provide increasingly convincing indications that Helicobacter pylori (H. pylori) is a causative factor in gastritis and peptic ulcer, the advances toward the clear understanding of this bacterium's pathogenic action are slow in coming. Having a niche bordering two major perimeters of gastric mucosal defense, H. pylori is capable of exerting detrimental effects on the mucus layer, as well as surface cells of the gastric epithelium. To cause such an effect, the bacteria… 
Alterations in gastric mucin synthesis by Helicobacter pylori.
It is important to consider whether H.pylori colonization of the surface epithelium is associated, as cause or effect, with changes in the gastric mucin synthesized by surface mucous cells.
The presence of spiral-shaped bacteria on human gastric mucosa was first recognized nearly one hundred years ago (Pel, 1899). These bacteria were isolated for the first time in 1982, in cultures of
4 Pathogenic mechanisms
The Influence of Mucus Microstructure and Rheology in Helicobacter pylori Infection
This review addresses the question of how the bacterium gets past the protective mucus barrier from a biophysical perspective and discusses how the biochemical strategy of urea hydrolysis required for survival in the acid is also relevant to the mechanism that enables flagella-driven swimming across the mucus gel layer.
Of blood and guts: Association between Helicobacter pylori and the gastric microcirculation
An important role for the gastric microcirculation in the pathophysiology of H. pylori‐induced injury is proposed and platelets participate in the inflammatory response by acting as a potent source of inflammatory mediators and modulating the activity of other inflammatory cells.
A Confirmatory Report for the Close Interaction of Helicobacter pylori With Gastric Epithelial MUC5AC Expression
The number of M UC5AC-expressing cells and the staining intensity of MUC5AC were shown to decrease in patients with H. pylori infection, which may potentially cause significant alterations of the structure and function of gastric mucins.
Pathogenesis of the transformation from gastritis to malignancy
Evidence is provided that the intestinal metaplasia or the gastric epithelium in atrophic gastritis reveal signs of abnormal expression of various regulatory genes well before the appearance of gastric neoplasia.
Morphological changes of Helicobacter pylori after antibacterial therapy: an
The results showed that the bacterium was usually present in different forms and sizes, and it was suggested that the coccoid form of H. pylori may be a static bacterium without urease production.