Mechanism of HIV-1 neutralization by antibodies targeting a membrane-proximal region of gp41.

@article{Chen2014MechanismOH,
  title={Mechanism of HIV-1 neutralization by antibodies targeting a membrane-proximal region of gp41.},
  author={Jia Jie Chen and Gary Frey and Hanqin Peng and Sophia Rits-Volloch and Jetta Garrity and Michael S. Seaman and Bing Chen},
  journal={Journal of virology},
  year={2014},
  volume={88 2},
  pages={1249-58}
}
Induction of broadly neutralizing antibodies (bNAbs) is an important goal for HIV-1 vaccine development. Two autoreactive bNAbs, 2F5 and 4E10, recognize a conserved region on the HIV-1 envelope glycoprotein gp41 adjacent to the viral membrane known as the membrane-proximal external region (MPER). They block viral infection by targeting a fusion-intermediate conformation of gp41, assisted by an additional interaction with the viral membrane. Another MPER-specific antibody, 10E8, has recently… CONTINUE READING