Mechanism of Esophageal Tumor Induction in Rats by N-Nitrosomethylbenzylamine and Its Ring-methylated Analog A/-Nitrosomethyl(4-methylbenzyl)amine1

Abstract

The metabolism of the esophageal carcinogen W-nitrosomethylbenzylamine (MBN) and its ring-methylated analog Nnitrosomethyl(4-methylbenzyl)amine (4-MeMBN) was investi gated in male Wistar rats. When given in the drinking water, both compounds have been shown to induce a high incidence of esophageal carcinomas but, after systemic administration of equimolar… (More)

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