Mechanism of Dose-Dependent Regulation of UBE1L by Polyphenols in Human Bronchial Epithelial Cells.

@article{Jiang2015MechanismOD,
  title={Mechanism of Dose-Dependent Regulation of UBE1L by Polyphenols in Human Bronchial Epithelial Cells.},
  author={Apei Jiang and Yuan Li and Pengqi Wang and Xiaoyun Shan and Pan Jiang and Xuemin Wang and Qing Feng},
  journal={Journal of cellular biochemistry},
  year={2015},
  volume={116 8},
  pages={1553-62}
}
Ubiquitin activating enzyme E1-like (UBE1L) is the activating enzyme for ISG15ylation (ISG15, interferon stimulated gene 15). UBE1L is thought to be a candidate tumor suppressor gene and has positive activity against stress responses such as viral infections. Both type I interferon and retinoic acid are known to induce UBE1L expression. However, the… CONTINUE READING