Mechanism of Divergent Growth Factor Effects in Mesenchymal Stem Cell Differentiation

@article{Kratchmarova2005MechanismOD,
  title={Mechanism of Divergent Growth Factor Effects in Mesenchymal Stem Cell Differentiation},
  author={Irina Kratchmarova and Blagoy S. Blagoev and Mandana Haack-S{\o}rensen and Moustapha Kassem and Matthias Mann},
  journal={Science},
  year={2005},
  volume={308},
  pages={1472 - 1477}
}
Closely related signals often lead to very different cellular outcomes. We found that the differentiation of human mesenchymal stem cells into bone-forming cells is stimulated by epidermal growth factor (EGF) but not platelet-derived growth factor (PDGF). We used mass spectrometry–based proteomics to comprehensively compare proteins that were tyrosine phosphorylated in response to EGF and PDGF and their associated partners. More than 90% of these signaling proteins were used by both ligands… 
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  • Biology, Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2008
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