Mechanism of DNA organization by Mycobacterium tuberculosis protein Lsr2

@inproceedings{Qu2013MechanismOD,
  title={Mechanism of DNA organization by Mycobacterium tuberculosis protein Lsr2},
  author={Yuanyuan Qu and Ci Ji Lim and Yixun R. Whang and Jun Liu and Jie Yan},
  booktitle={Nucleic acids research},
  year={2013}
}
Bacterial nucleoid-associated proteins, such as H-NS-like proteins in Enterobacteriaceae, are abundant DNA-binding proteins that function in chromosomal DNA organization and gene transcription regulation. The Mycobacterium tuberculosis Lsr2 protein has been proposed to be the first identified H-NS analogue in Gram-positive bacteria based on its capability to complement numerous in vivo functions of H-NS. Here, we report that Lsr2 cooperatively binds to DNA forming a rigid Lsr2 nucleoprotein… CONTINUE READING