Mechanism of Congo Red Binding to Amyloid Proteins with a Beta Pleated Sheet Structure

@inproceedings{Elhaddaoui1993MechanismOC,
  title={Mechanism of Congo Red Binding to Amyloid Proteins with a Beta Pleated Sheet Structure},
  author={Abdelkader Elhaddaoui and Andr{\'e} Delacourte and Enrico Pigorsch and Jamal Sajid and Sylvia Turrell},
  year={1993}
}
The extracellular deposition of amyloid protein in the brain is the major pathological hallmark of Alzheimer’s disease. Deposits of amyloid βA4, a peptide composed of 42 or 43 amino acid residues1, in the cerebral cortex and hippocampus take the form of neuritic and cerebrovascular plaques (extracellular deposit) and neurofibrillary tangles (intracellular deposit). These highly insoluble, filamentous aggregates are revealed by staining with one of two histological dyes -- thioflavin or Congo… CONTINUE READING