Mechanism of Cephalosporin‐induced Hypoprothrombinemia: Relation to Cephalosporin Side Chain, Vitamin K Metabolism, and Vitamin K Status

@article{Shearer1988MechanismOC,
  title={Mechanism of Cephalosporin‐induced Hypoprothrombinemia: Relation to Cephalosporin Side Chain, Vitamin K Metabolism, and Vitamin K Status},
  author={M. Shearer and H. Bechtold and K. Andrassy and J. Koderisch and P. Mccarthy and D. Trenk and E. J{\"a}hnchen and E. Ritz},
  journal={The Journal of Clinical Pharmacology},
  year={1988},
  volume={28}
}
The mechanism of cephalosporin‐induced hypoprothrombinemia has been investigated in hospitalized patients, with respect to cephalosporin structure, vitamin K metabolism, and vitamin K status. Cephalosporins containing side chains of N‐methylthiotetrazole (latamoxef, cefmenoxime, cefoperazone, cefotetan, cefamandole) or methyl‐thiadiazole (cefazolin) all caused the transient plasma appearance of vitamin K1 2,3‐epoxide in response to a 10‐mg intravenous dose of vitamin K1, whereas two… Expand
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