Mechanism of Cephalosporin‐induced Hypoprothrombinemia: Relation to Cephalosporin Side Chain, Vitamin K Metabolism, and Vitamin K Status

@article{Shearer1988MechanismOC,
  title={Mechanism of Cephalosporin‐induced Hypoprothrombinemia: Relation to Cephalosporin Side Chain, Vitamin K Metabolism, and Vitamin K Status},
  author={Martin J Shearer and Heinrich Bechtold and Konrad Andrassy and Janti Koderisch and Patrick T. McCarthy and Dietmar Trenk and Eberhard J{\"a}hnchen and Eberhard Ritz},
  journal={The Journal of Clinical Pharmacology},
  year={1988},
  volume={28}
}
The mechanism of cephalosporin‐induced hypoprothrombinemia has been investigated in hospitalized patients, with respect to cephalosporin structure, vitamin K metabolism, and vitamin K status. Cephalosporins containing side chains of N‐methylthiotetrazole (latamoxef, cefmenoxime, cefoperazone, cefotetan, cefamandole) or methyl‐thiadiazole (cefazolin) all caused the transient plasma appearance of vitamin K1 2,3‐epoxide in response to a 10‐mg intravenous dose of vitamin K1, whereas two… 

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TLDR
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Lack of Effect of Cefixime on the Metabolism of Vitamin K1

TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Cephalosporins containing the NMTT side chain are associated with the development of hypoprothrombinemia and possibly bleeding, especially in high-risk patients.

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TLDR
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TLDR
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TLDR
The effects of aztreonam on fecal flora and on descarboxy prothrombin (PIVKA-II) in plasma and gamma-carboxyglutamic acid (Gla) in urine as an index of vitamin K metabolism were studied in children with urinary tract infections.

Pharmacokinetics and hemostasis following administration of a new, injectable oxacephem (6315-S, flomoxef) in volunteers and in patients with renal insufficiency

TLDR
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