Mechanism of Cellular Uptake and Impact of Ferucarbotran on Macrophage Physiology

Abstract

Superparamagnetic iron oxide (SPIO) nanoparticles are contrast agents used for magnetic resonance imaging. Ferucarbotran is a clinically approved SPIO-coated carboxydextran with a diameter of about 45-60 nm. We investigated the mechanism of cellular uptake of Ferucarbotran with a cell model using the murine macrophage cell line Raw 264.7. We observed a dose… (More)
DOI: 10.1371/journal.pone.0025524

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