Mechanism of Catch Force: Tethering of Thick and Thin Filaments by Twitchin

@inproceedings{Butler2010MechanismOC,
  title={Mechanism of Catch Force: Tethering of Thick and Thin Filaments by Twitchin},
  author={Thomas M. Butler and Marion J. Siegman},
  booktitle={Journal of biomedicine & biotechnology},
  year={2010}
}
Catch is a mechanical state occurring in some invertebrate smooth muscles characterized by high force maintenance and resistance to stretch during extremely slow relaxation. During catch, intracellular calcium is near basal concentration and myosin crossbridge cyctng rate is extremely slow. Catch force is relaxed by a protein kinase A-mediated phosphorylation of sites near the N- and C- temini of the minititin twitchin (approximately 526 kDa). Some catch force maintenance car also occur… CONTINUE READING
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