Mechanism of Cardioprotective Effect of Orotic Acid Mechanism of Action of Orotic Acid

@inproceedings{RosenfeldtMechanismOC,
  title={Mechanism of Cardioprotective Effect of Orotic Acid Mechanism of Action of Orotic Acid},
  author={Franklin Rosenfeldt and Stephen M. Richards and Zaw Lin and Salvatore Pepe and J. RobertA. and Conyers}
}
The pyrimidine base, orotic acid (OA), markedly improves the function of recently infarcted hearts subjected to global ischemia. The mechanism of cardiac action of OA is unclear, but it has been proposed that OA acts by correcting a relative de~ciency of nucleotide precursors required for RNA synthesis in the stressed myocardium or by improving myocardial… CONTINUE READING