Mechanism of CD1d-restricted natural killer T cell activation during microbial infection

@article{Brigl2003MechanismOC,
  title={Mechanism of CD1d-restricted natural killer T cell activation during microbial infection},
  author={Manfred Brigl and Lynn Bry and Sally C. Kent and Jenny E Gumperz and Michael B Brenner},
  journal={Nature Immunology},
  year={2003},
  volume={4},
  pages={1230-1237}
}
CD1d-restricted natural killer T (NKT) cells are important for host defense against a variety of microbial pathogens. How and when these T cells become activated physiologically during infection remains unknown. Our data support a model in which NKT cells use a unique activation mechanism not requiring their recognition of microbial antigens. Instead, weak responses to CD1d-presented self antigens were amplified by interleukin 12 made by dendritic cells in response to microbial products… CONTINUE READING
Highly Influential
This paper has highly influenced 34 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 326 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Interleukin - 18

J. A. Gracie, S. E. Robertson, I. B. McInnes
J . Leukoc . Biol . • 2003

CD 1 d - dependent macrophage - mediated clearance of Pseudomonas aeruginosa from lung

E. E. Nieuwenhuis
Nat . Med . • 2002

Activation of V α 14 + natural killer T cells by α - galactosylceramide results in development of Th 1 response and local host resistance in mice infected with Cryptococcus neoformans

K. Kawakami
Infect . Immun . • 2001

Similar Papers

Loading similar papers…