Mechanism of CD1d-restricted natural killer T cell activation during microbial infection

  title={Mechanism of CD1d-restricted natural killer T cell activation during microbial infection},
  author={Manfred Brigl and Lynn Bry and Sally C. Kent and Jenny E Gumperz and Michael B Brenner},
  journal={Nature Immunology},
CD1d-restricted natural killer T (NKT) cells are important for host defense against a variety of microbial pathogens. How and when these T cells become activated physiologically during infection remains unknown. Our data support a model in which NKT cells use a unique activation mechanism not requiring their recognition of microbial antigens. Instead, weak responses to CD1d-presented self antigens were amplified by interleukin 12 made by dendritic cells in response to microbial products… CONTINUE READING
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