Mechanism of BDNF Modulation in GABAergic Synaptic Transmission in Healthy and Disease Brains

@inproceedings{Porcher2018MechanismOB,
  title={Mechanism of BDNF Modulation in GABAergic Synaptic Transmission in Healthy and Disease Brains},
  author={Christophe Porcher and Igor Medina and Jean-Luc Gaiarsa},
  booktitle={Front. Cell. Neurosci.},
  year={2018}
}
In the mature healthy mammalian neuronal networks, γ-aminobutyric acid (GABA) mediates synaptic inhibition by acting on GABAA and GABAB receptors (GABAAR, GABABR). In immature networks and during numerous pathological conditions the strength of GABAergic synaptic inhibition is much less pronounced. In these neurons the activation of GABAAR produces paradoxical depolarizing action that favors neuronal network excitation. The depolarizing action of GABAAR is a consequence of deregulated chloride… CONTINUE READING
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