Mechanism of Ad5 Vaccine Immunity and Toxicity: Fiber Shaft Targeting of Dendritic Cells

@article{Cheng2007MechanismOA,
  title={Mechanism of Ad5 Vaccine Immunity and Toxicity: Fiber Shaft Targeting of Dendritic Cells},
  author={Cheng Cheng and Jason G. D. Gall and Wing-pui Kong and Rebecca L Sheets and Phillip L Gomez and C. Richter King and Gary J. Nabel},
  journal={PLoS Pathogens},
  year={2007},
  volume={3},
  pages={149 - 156}
}
Recombinant adenoviral (rAd) vectors elicit potent cellular and humoral immune responses and show promise as vaccines for HIV-1, Ebola virus, tuberculosis, malaria, and other infections. These vectors are now widely used and have been generally well tolerated in vaccine and gene therapy clinical trials, with many thousands of people exposed. At the same time, dose-limiting adverse responses have been observed, including transient low-grade fevers and a prior human gene therapy fatality, after… CONTINUE READING

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