Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor

@article{Brooks2014MechanismOA,
  title={Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor},
  author={Andrew J. Brooks and Wei Dai and Megan L. O’Mara and Daniel Abankwa and Yash Chhabra and Rebecca A. Pelekanos and Olivier Gardon and Kathryn A. Tunny and Kristopher M. Blucher and Craig J. Morton and Michael W. Parker and Emma Sierecki and Yann Gambin and Guillermo A. Gomez and Kirill Alexandrov and Ian A. Wilson and Manolis Doxastakis and Alan E. Mark and Michael J. Waters},
  journal={Science},
  year={2014},
  volume={344}
}
Introduction Class I cytokines regulate key processes such as growth, lactation, hematopoiesis, and immune function and contribute to oncogenesis. Although the extracellular domain structures of their receptors are well characterized, little is known about how the receptors activate their associated JAK (Janus kinase) protein kinases. We provide a mechanistic description for this process, focusing on the growth hormone (GH) receptor and its associated JAK2. Receptor-JAK2 activation process… 
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TLDR
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TLDR
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TLDR
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TLDR
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The growth hormone receptor.
  • M. Waters
  • Biology
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 2016
Fos-Zippered GH Receptor Cytosolic Tails Act as Jak2 Substrates and Signal Transducers.
TLDR
Analysis by blue-native gel electrophoresis revealed high molecular-weight complexes containing both Jak2 and nonphosphorylated GHR tails, whereas Jak2-dissociated tails were highly phosphorylated and monomeric, implying that Jak2 detaches from its substrate upon phosphorylation.
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