Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor

@article{Brooks2014MechanismOA,
  title={Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor},
  author={A. Brooks and W. Dai and M. O’Mara and D. Abankwa and Y. Chhabra and R. A. Pelekanos and O. Gardon and K. A. Tunny and K. M. Blucher and C. Morton and M. Parker and E. Sierecki and Y. Gambin and G. A. Gomez and K. Alexandrov and I. Wilson and M. Doxastakis and A. Mark and M. Waters},
  journal={Science},
  year={2014},
  volume={344}
}
Introduction Class I cytokines regulate key processes such as growth, lactation, hematopoiesis, and immune function and contribute to oncogenesis. Although the extracellular domain structures of their receptors are well characterized, little is known about how the receptors activate their associated JAK (Janus kinase) protein kinases. We provide a mechanistic description for this process, focusing on the growth hormone (GH) receptor and its associated JAK2. Receptor-JAK2 activation process… Expand
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