Mechanism of Action of Pentostatin and Cladribine in Hairy Cell Leukemia

  title={Mechanism of Action of Pentostatin and Cladribine in Hairy Cell Leukemia},
  author={James B. Johnston},
  journal={Leukemia \& Lymphoma},
  pages={43 - 45}
  • J. Johnston
  • Published 23 May 2011
  • Biology, Chemistry
  • Leukemia & Lymphoma
Pentostatin (2′-deoxycoformycin; dCF) and cladribine (2-chlorodeoxyadenosine; CdA) are highly effective agents for the treatment of hairy cell leukemia. Although their precise mechanisms of action in this disease are still unknown, a number of mechanisms have been postulated. dCF is a potent inhibitor of adenosine deaminase (ADA), and treatment results in the accumulation of deoxyadenosine (dAdo) and adenosine (Ado) in the plasma. dAdo is phosphorylated by deoxycytidine kinase in lymphocytes to… 

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