Mechanism of Action of Paracetamol

  title={Mechanism of Action of Paracetamol},
  author={G. Graham and K. F. Scott},
  journal={American Journal of Therapeutics},
  • G. Graham, K. F. Scott
  • Published 2005
  • Medicine
  • American Journal of Therapeutics
  • Paracetamol (acetaminophen) is generally considered to be a weak inhibitor of the synthesis of prostaglandins (PGs). However, the in vivo effects of paracetamol are similar to those of the selective cyclooxygenase-2 (COX-2) inhibitors. Paracetamol also decreases PG concentrations in vivo, but, unlike the selective COX-2 inhibitors, paracetamol does not suppress the inflammation of rheumatoid arthritis. It does, however, decrease swelling after oral surgery in humans and suppresses inflammation… CONTINUE READING
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