Mechanism of Action of Opioids and Clinical Effects

  title={Mechanism of Action of Opioids and Clinical Effects},
  author={Enno Christian Kurt Freye and Joseph Victor Levy},
  journal={Opioids in Medicine},
  pages={85 - 187}
Comprehensive Review of Knee Osteoarthritis Pharmacological Treatment and the Latest Professional Societies’ Guidelines
Biological options, such as platelet-rich plasma and mesenchymal stem cell injections, have shown good results in the treatment of osteoarthritis symptoms, greatly increasing the patient’s quality of life, especially when combined with other therapeutic options. Expand
Drugs behind the veil of Islam: a view of Saudi youth
It is discovered that drug trafficking is correlated to economic disparity among regions and social strata in the Kingdom, methods of drug purchase differ regionally, and drug use is an unintended consequence of social changes. Expand
Analgesic Effect Comparison Between Nalbuphine and Sufentanil for Patient-Controlled Intravenous Analgesia After Cesarean Section
PCIA with nalbuphine provides better analgesia and higher patient satisfaction than sufentanil after cesarean section and no significant differences in the PCIA drug consumption were found. Expand
Autonomic impairment in a transgenic mouse model of amyotrophic lateral sclerosis
The results suggest autonomic nervous system impairment in this ALS model, consistent with clinical data in humans. Expand


Antagonism of fentanyl-induced respiratory depression with nalmefene.
It is shown that nalmefene is an effective long-acting opioid antagonist, and that RIP accurately measures changes in respiration caused by opioid administration, and the changes were almost completely prevented. Expand
Opioide in der Anästhesie
Three classes of opioid receptors (μ, δ, κ), expressed in the central and peripheral nervous system, have been identified and are the most effective and widely used drugs in the treatment of severe acute and chronic pain. Expand
2. Wechselwirkungen zwischen dem System der schnellen Schmerzempfindung und dem des langsamen, nachhaltigen Schmerzgefühls
  • R. Haßler
  • Medicine
  • Langenbecks Archiv für Chirurgie
  • 2005
The subcortical pain pathway is disinhibited after destruction of the cortical pathway of the 1st pain, so that the patients suffer from spontaneous agonizing pain feelings (thalamic pain), which can be relieved by stereotactic coagulation of the thalamic nuclei involved in the 2nd pain. Expand
Effect of low-dose droperidol on the QT interval during and after general anesthesia: a placebo-controlled study.
Use of a small dose of droperidol for antiemetic prophylaxis during general anesthesia was not associated with a statistically significant increase in the QTc interval compared with saline, and more importantly, there was no evidence of any dro peridol-induced QTC prolongation immediately after surgery. Expand
Interaction of μ‐opioid receptor agonists and antagonists with the analgesic effect of buprenorphine in mice
This study investigated the interaction potential with several full μ‐agonists in the tail‐flick test in mice and examined the reversibility of buprenorphine antinociception by different μ‐opioid receptor antagonists. Expand
Prolongation of QTc Interval after Postoperative Nausea and Vomiting Treatment by Droperidol or Ondansetron
When used in treatment of postoperative nausea and vomiting, a situation where prolongation of the QTc interval seems to occur, the safety of 5-hydroxytryptamine type 3 antagonists may not be superior to that of low-dose droperidol. Expand
The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report.
In patients who failed prophylaxis with ondansetron or droperidol, promethazine was significantly more effective than the agent used for prophYLaxis for the treatment of PONV and dimenhydrinate was also more effective for the Treatment of established PonV in the postoperative anesthesia care unit. Expand
Opioid-Induced Respiratory Depression and Analgesia May Be Mediated by Different Subreceptors
Use of selective delta opioid antagonists provide evidence that the delta receptor within the brain seems an integrated part in the mediation of respiratory depression induced by a potent analgesicExpand
Part II
Abstract This study utilizes a framework for culinary product innovations as a distinctive capability specifically to foodservice operations. Following a more thorough discussion of the innovationExpand
Perfusion of the fourth cerebral ventricle with fentanyl induces naloxone-reversible bradycardia, hypotension, and EEG synchronisation in conscious dogs
It is concluded that opiate receptors bordering the fourth cerebral ventricle mediate the cardiovascular and hypnotic action of fentanyl. Expand