Mechanism of Action of Mycophenolate Mofetil

  title={Mechanism of Action of Mycophenolate Mofetil},
  author={J. Ransom},
  journal={Therapeutic Drug Monitoring},
  • J. Ransom
  • Published 1995
  • Chemistry, Medicine
  • Therapeutic Drug Monitoring
Summary Mycophenolate mofetil is a prodrug which is rapidly converted to mycophenolic acid (MPA), a potent and reversible uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH). In the de novo purine synthesis pathway, IMPDH is the first of two enzymes responsible for the conversion of inosine monophosphate (IMP) to guanosine monophosphate (GMP), which is normally converted to GDP, GTP, and dGTP. IMPDH is not involved in the salvage pathway of purine biosynthesis. It has been… Expand
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