Mechanism of Action of Atypical Antipsychotic Drugs and the Neurobiology of Schizophrenia

@article{Horek2006MechanismOA,
  title={Mechanism of Action of Atypical Antipsychotic Drugs and the Neurobiology of Schizophrenia},
  author={J. Hor{\'a}{\vc}ek and V. Buben{\'i}kov{\'a}-Vale{\vs}ov{\'a} and M. Kope{\vc}ek and T. P{\'a}len{\'i}{\vc}ek and C. Dockery and P. Mohr and C. H{\"o}schl},
  journal={CNS Drugs},
  year={2006},
  volume={20},
  pages={389-409}
}
Atypical antipsychotics have greatly enhanced the treatment of schizophrenia. The mechanisms underlying the effectiveness and adverse effects of these drugs are, to date, not sufficiently explained. This article summarises the hypothetical mechanisms of action of atypical antipsychotics with respect to the neurobiology of schizophrenia.When considering treatment models for schizophrenia, the role of dopamine receptor blockade and modulation remains dominant. The optimal occupancy of dopamine D2… Expand
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