Mechanism of Action for NNZ-2566 Anti-inflammatory Effects Following PBBI Involves Upregulation of Immunomodulator ATF3

@article{Cartagena2013MechanismOA,
  title={Mechanism of Action for NNZ-2566 Anti-inflammatory Effects Following PBBI Involves Upregulation of Immunomodulator ATF3},
  author={C. Cartagena and K. L. Phillips and Garry L. Williams and Melissa Konopko and F. Tortella and J. Dave and Kara E. Schmid},
  journal={NeuroMolecular Medicine},
  year={2013},
  volume={15},
  pages={504-514}
}
The tripeptide glycine–proline–glutamate analogue NNZ-2566 (Neuren Pharmaceuticals) demonstrates neuroprotective efficacy in models of traumatic brain injury. In penetrating ballistic-like brain injury (PBBI), it significantly decreases injury-induced upregulation of inflammatory cytokines including TNF-α, IFN-γ, and IL-6. However, the mechanism by which NNZ-2566 acts has yet to be determined. The activating transcription factor-3 (ATF3) is known to repress expression of these inflammatory… Expand
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  • 35
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  • H. Lin, C. Cheng
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  • Ci ji yi xue za zhi = Tzu-chi medical journal
  • 2018
  • 2
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  • 26
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  • 71
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  • 24
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  • 7
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  • 59
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  • 6
...
1
2
...

References

SHOWING 1-10 OF 56 REFERENCES
NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats
  • 62
NNZ-2566, a glypromate analog, improves functional recovery and attenuates apoptosis and inflammation in a rat model of penetrating ballistic-type brain injury.
  • 39
NNZ-2566: A Gly–Pro–Glu analogue with neuroprotective efficacy in a rat model of acute focal stroke
  • 23
Neuroprotective effects of Gly-Pro-Glu, the N-terminal tripeptide of IGF-1, in the hippocampus in vitro.
  • 50
Negative Regulation of TLR-Signaling Pathways by Activating Transcription Factor-31
  • 186
  • PDF
Astrocytes produce and release interleukin-1, interleukin-6, tumor necrosis factor alpha and interferon-gamma following traumatic and metabolic injury.
  • 242
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4
  • 664
  • PDF
Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain.
  • 44
Distinct cellular patterns of upregulated chemokine expression supporting a prominent inflammatory role in traumatic brain injury.
  • 134
T-cell cytokines in injury-induced neural damage and repair
  • 78
...
1
2
3
4
5
...