Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles.

Abstract

The ATP-binding cassette transporter A1 (ABCA1) plays a critical role in the biogenesis of high density lipoprotein (HDL) particles and in mediating cellular cholesterol efflux. The mechanism by which ABCA1 achieves these effects is not established, despite extensive investigation. Here, we present a model that explains the essential features, especially… (More)

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@article{Vedhachalam2007MechanismOA, title={Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles.}, author={Charulatha Vedhachalam and P. Duong and Margaret Nickel and David Nguyen and P. Dhanasekaran and Hiroyuki Saito and George H. Rothblat and Sissel Lund-Katz and Michael C Phillips}, journal={The Journal of biological chemistry}, year={2007}, volume={282 34}, pages={25123-30} }