Mechanism of AP-1-mediated gene expression by select organochlorines through the p38 MAPK pathway.

@article{Frigo2004MechanismOA,
  title={Mechanism of AP-1-mediated gene expression by select organochlorines through the p38 MAPK pathway.},
  author={Daniel E. Frigo and Yan Tang and Barbara S. Beckman and Aline B. Scandurro and Jawed Alam and Matthew E. Burow and J A McLachlan},
  journal={Carcinogenesis},
  year={2004},
  volume={25 2},
  pages={249-61}
}
Organochlorine compounds have been demonstrated to have detrimental health effects in both wildlife and humans, an effect largely attributed to their ability to mimic the hormone estrogen. Our laboratory has studied cell signaling by environmental chemicals associated with the estrogen receptor (ER) and more recently via ER-independent mechanisms. Here, we show that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) and its metabolites induce a stress mitogen-activated protein… CONTINUE READING

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