Mechanism of 5‐HT Contraction in Isolated Bovine Ventricular Coronary Arteries: Evidence for Transient Receptor‐Operated Calcium Influx Channels

@article{Ratz1984MechanismO5,
  title={Mechanism of 5‐HT Contraction in Isolated Bovine Ventricular Coronary Arteries: Evidence for Transient Receptor‐Operated Calcium Influx Channels},
  author={Paul H Ratz and Stephen F. Flaim},
  journal={Circulation Research},
  year={1984},
  volume={54},
  pages={135–143}
}
The effect of serotonin on isometric tension and transmembrane calcium influx was investigated in rings cut from branches of male bovine circumflex and left anterior descending coronary arteries. Responses were compared to those produced by potassium chloride, and to the serotonin contraction produced in rabbit thoracic aorta. Serotonin in bovine ventricular coronary arteries produced a strong, transient contraction, even at a maximum concentration. Contraction did not decline because of… 
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33 Citations
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33 Citations

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Citation Type

Effects of calcium antagonists on isolated bovine cerebral arteries: inhibition of constriction and calcium-45 uptake induced by potassium or serotonin.
TLDR
The results demonstrate that verapamil and nifedipine block 45Ca uptake through both potential-operated and receptor-operated channels in bovine middle cerebral arteries.
Maturation Modulates Serotonin- and Potassium-Induced Calcium-45 Uptake in Ovine Carotid and Cerebral Arteries
TLDR
Under all conditions examined, calcium uptakes were uniformly greater in newborn than adult arteries, and were greater in MCA than COM segments of the same age, largely to age-related variations in the activation of calcium entry through voltage-sensitive and receptor-operated membrane calcium channels.
Influence of Serotonin on Myocardial Blood Flow in the Presence and Absence of a Coronary Arterial Stenosis: Observations in Domestic Swine 1
TLDR
When coronary vasodilatory reserve is impaired by the presence of a severe proximal stenosis, 5-HT causes modest impairment of endocardial flow regulation, but does not impair coronary flow regulation when full vasodilant reserve is present.
Vasodilator action of calcium antagonists in coronary arteries in vitro.
  • S. Kalsner
  • Biology, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1997
TLDR
It is concluded that at least some of the therapeutic effects of calcium antagonists on arterial tone may be the consequence of antagonism at vascular smooth muscle cell site(s) at which calcium is released or interacts, rather than of block of calcium entry through membrane L channels.
Simultaneous measurement of force and calcium uptake during acetylcholine-induced endothelium-dependent relaxation of rabbit thoracic aorta.
TLDR
It is suggested that endothelium-derived relaxing factor relaxes 1 microM norepinephrine-contracted rings of rabbit thoracic aorta by decreasing calcium entry and by producing an extracellular calcium-independent relaxant effect.
Vasomotor effect of histamine on pig and cattle coronary artery in vitro.
TLDR
The results suggest that histamine-induced vasoconstriction in pig and cattle coronary arteries is mainly dependent on the H1-receptors in the smooth muscle cells, and that H 1- and H2-receptor cells in the endothelial cells of pigs and H 2-receptions in the Smooth muscle cells of cattle modify the histamines-induced Vasoconstrictions.
Pharmacological analysis of 5-HT-induced vasoconstriction in isolated, perfused dog skeletal muscle arteries.
Effect of pentobarbital on the contraction and calcium movements in cat cerebral and peripheral arteries
Participation of H1-receptors in histamine-induced contraction and relaxation of horse coronary artery in vitro.
TLDR
The results suggest that the histamine-induced contraction and relaxation in horse coronary arteries are mediated mainly by H1-receptors in the smooth muscle and endothelium, respectively, and H 1-receptor activation of endothelial cells may liberate vasodilator substances.
Effects of potassium and norepinephrine on calcium influx in guinea-pig vas deferens.
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