Mechanism of 4-chlorobenzoate:coenzyme a ligase catalysis.

  title={Mechanism of 4-chlorobenzoate:coenzyme a ligase catalysis.},
  author={Rui Wu and Jian Cao and Xuefeng Lu and Albert S. Reger and Andrew M Gulick and Debra Dunaway-Mariano},
  volume={47 31},
Within the accompanying paper in this issue (Reger et al. (2008) Biochemistry, 47, 8016-8025) we reported the X-ray structure of 4-chlorobenzoate:CoA ligase (CBL) bound with 4-chlorobenzoyl-adenylate (4-CB-AMP) and the X-ray structure of CBL bound with 4-chlorophenacyl-CoA (4-CP-CoA) (an inert analogue of the product 4-chlorobenzoyl-coenzyme A (4-CB-CoA)) and AMP. These structures defined two CBL conformational states. In conformation 1, CBL is poised to catalyze the adenylation of 4… CONTINUE READING
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Domain movement and substrate recognition in 4-chlorobenzoate: coenzyme A ligase from Alcaligenes sp strain AL3007

  • R. Wu
  • Ph.D. Thesis, University of New Mexico,
  • 2008

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