Mechanism of 2-oxoglutarate signaling by the Synechococcus elongatus PII signal transduction protein.

@article{Fokina2010MechanismO2,
  title={Mechanism of 2-oxoglutarate signaling by the Synechococcus elongatus PII signal transduction protein.},
  author={Oleksandra Fokina and Vasuki-Ranjani Chellamuthu and Karl Forchhammer and Kornelius Zeth},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 46},
  pages={19760-5}
}
P(II) proteins control key processes of nitrogen metabolism in bacteria, archaea, and plants in response to the central metabolites ATP, ADP, and 2-oxoglutarate (2-OG), signaling cellular energy and carbon and nitrogen abundance. This metabolic information is integrated by P(II) and transmitted to regulatory targets (key enzymes, transporters, and transcription factors), modulating their activity. In oxygenic phototrophs, the controlling enzyme of arginine synthesis, N-acetyl-glutamate kinase… CONTINUE READING
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A new PII protein structure identifies the 2-oxoglutarate binding site

  • D Truan
  • J Mol Biol
  • 2010

Structural basis for the regulation of NtcA-dependent transcription by proteins PipX and PII

  • JL Llacer
  • Proc Natl Acad Sci USA
  • 2010

XDS. Acta Crystallogr

  • W Kabsch
  • Sect D: Biol Crystallogr
  • 2010

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