Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced decrease in anti-CD3-activated CD4(+) T cells: the roles of apoptosis, Fas, and TNF.

@article{Dearstyne2002MechanismO2,
  title={Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced decrease in anti-CD3-activated CD4(+) T cells: the roles of apoptosis, Fas, and TNF.},
  author={Erica A Dearstyne and Nancy I Kerkvliet},
  journal={Toxicology},
  year={2002},
  volume={170 1-2},
  pages={
          139-51
        }
}
The environmental contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), suppresses T cell functions and reduces T cell numbers in multiple models of immune stimulation. However, the underlying mechanism(s) by which TCDD induces these changes has yet to be elucidated. We hypothesized that TCDD affects T cells through the induction or augmentation of apoptosis. In these studies, we used antibody to CD4, annexin V, and 7-AAD in three-color flow cytometric analyses to examine the relationship… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 20 CITATIONS

Effects of TCDD on the fate of naive dendritic cells.

  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2010
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Early consequences of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on the activation and survival of antigen-specific T cells.

  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2004
VIEW 4 EXCERPTS
CITES BACKGROUND