Mechanism of 1,3-dichloropropene-induced rat liver carcinogenesis.


1,3-Dichloropropene (1,3-D) is a soil fumigant used primarily for preplanting control of parasitic nematodes. In a previous chronic dietary exposure study, 1,3-D induced an increased incidence of hepatocellular adenomas in male rats at a dose of 25 mg/kg/day. Although the mechanism for tumor induction in the rat liver by 1,3-D has not been specifically… (More)
DOI: 10.1093/toxsci/kfu221


Cite this paper

@article{Klaunig2015MechanismO1, title={Mechanism of 1,3-dichloropropene-induced rat liver carcinogenesis.}, author={James E. Klaunig and Sean C Gehen and Zemin Wang and Patrick J. Klein and Richard Billington}, journal={Toxicological sciences : an official journal of the Society of Toxicology}, year={2015}, volume={143 1}, pages={6-15} }