Mechanism of <ce:italic>γδ</ce:italic> T cell-induced human oligodendrocyte cytotoxicity: relevance to multiple sclerosis

@article{Zeine1998MechanismO,
  title={Mechanism of <ce:italic>γδ</ce:italic> T cell-induced human oligodendrocyte cytotoxicity: relevance to multiple sclerosis},
  author={Rana Zeine and Robert A. Pon and Uma Ladiwala and Jack P. Antel and M. S. Freedman},
  journal={Journal of Neuroimmunology},
  year={1998},
  volume={87},
  pages={49-61}
}
Ž . gd T cells may contribute to the pathogenesis of Multiple Sclerosis MS via cytotoxicity directed at the myelin-oligodendrocyte unit. We have previously demonstrated that peripheral blood-derived gd T cells lyse fresh human oligodendrocytes in vitro. The present work Ž . Ž . extends these observations to gd T cells derived from both peripheral blood PBL and cerebrospinal fluid CSF of MS and non-MS neurological disease controls and addresses the mechanism of cellular cytotoxicity. We found… CONTINUE READING

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