Mechanism limiting centrosome duplication to once per cell cycle

  title={Mechanism limiting centrosome duplication to once per cell cycle},
  author={Meng-Fu Bryan Tsou and Tim Stearns},
The centrosome organizes the microtubule cytoskeleton and consists of a pair of centrioles surrounded by pericentriolar material. Cells begin the cell cycle with a single centrosome, which duplicates once before mitosis. During duplication, new centrioles grow orthogonally to existing ones and remain engaged (tightly opposed) with those centrioles until late mitosis or early G1 phase, when they become disengaged. The relationship between centriole engagement/disengagement and centriole… CONTINUE READING
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