Mechanism governing heme synthesis reveals a GATA factor/heme circuit that controls differentiation.

@article{Tanimura2016MechanismGH,
  title={Mechanism governing heme synthesis reveals a GATA factor/heme circuit that controls differentiation.},
  author={Nobuyuki Tanimura and Eli Miller and Kazuhiko Igarashi and David T Yang and Judith N Burstyn and Colin N. Dewey and Emery H. Bresnick},
  journal={EMBO reports},
  year={2016},
  volume={17 2},
  pages={249-65}
}
Metal ion-containing macromolecules have fundamental roles in essentially all biological processes throughout the evolutionary tree. For example, iron-containing heme is a cofactor in enzyme catalysis and electron transfer and an essential hemoglobin constituent. To meet the intense demand for hemoglobin assembly in red blood cells, the cell type-specific factor GATA-1 activates transcription of Alas2, encoding the rate-limiting enzyme in heme biosynthesis, 5-aminolevulinic acid synthase-2… CONTINUE READING