Mechanism governing a stem cell-generating cis-regulatory element.

@article{Sanalkumar2014MechanismGA,
  title={Mechanism governing a stem cell-generating cis-regulatory element.},
  author={Rajendran Sanalkumar and Kirby D. Johnson and Xin Gao and Meghan E. Boyer and Y. Chang and Kyle J. Hewitt and Jing Zhang and Emery H. Bresnick},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 12},
  pages={E1091-100}
}
The unremitting demand to replenish differentiated cells in tissues requires efficient mechanisms to generate and regulate stem and progenitor cells. Although master regulatory transcription factors, including GATA binding protein-2 (GATA-2), have crucial roles in these mechanisms, how such factors are controlled in developmentally dynamic systems is poorly understood. Previously, we described five dispersed Gata2 locus sequences, termed the -77, -3.9, -2.8, -1.8, and +9.5 GATA switch sites… CONTINUE READING
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